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Pressing causes the cartridge's seal to break and permits the nicotine to escape the cartridge (Figure 4)

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While at the inception of the Lotus Project, pouch products' users were expected to graduate to the higher nicotine brands of loose MST, Skoal and Copenhagen, [13, 33] over time pouch product variants of higher nicotine MST have also been introduced, including large size pouches of Skoal, Grizzly, and Copenhagen (Table 1)